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Desirable characteristics of TODABONE®
Osteo-integration
Which is the ability to establish a chemical bond with the physiological tissue without the formation of a fibrous layer around the implant
Osteo-conduction
Which is the ability to support the growth of new bone on the surface of the grafting material by allowing the growth of orientated blood vessels and the creation of new Haversian Systems
Osteo-induction
Which stimulates and activates pluripotent stem cells leading to their differentiation to an osteoblastic phenotype. During this process, which is mediated by a signaling cascade, some extracellular and intracellular receptors are involved, the most important of which belong to the TGF-beta superfamily
Osteogenesis
That involves the synthesis of new bone by osteoblasts that are present within the graft (if cell-seeded biomaterial constructs are used) or have colonized it after implantation